The New York Giants escaped disaster last week, completing a 20-0 halftime comeback to steal a win against the presumed bottom-of-the-barrel Cardinals. The Week 3 odds have them traveling to take on the San Francisco 49ers, who have strung together two impressive wins to start the season.
The Giants will embark on their trip without both their star running back Saquon Barkley and emerging left tackle Andrew Thomas, while San Francisco may be without breakout wideout Brandon Aiyuk.
Who will step up and emerge on the national stage for Thursday Night Football? TNF odds have the Niners tabbed as -10.5 point favorites with the total sitting at 44.5.
Continue reading for free NFL prop picks and predictions for the Giants vs. 49ers Thursday Night Football game on September 21 and check out our full game preview in our Giants vs. 49ers predictions — and our Christian McCaffrey odds and props spotlight.